Functional redundancy between RAP1 isoforms in murine platelet production and function

RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a normal platelet count, suggesting the existence of a...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Stefanini, Lucia, Lee, Robert H., Paul, David S., O'Shaughnessy, Ellen C., Ghalloussi, Dorsaf, Jones, Christopher I., Boulaftali, Yacine, Poe, Kathryn O., Piatt, Raymond, Kechele, Dan O., Caron, Kathleen M., Hahn, Klaus M., Gibbins, Jonathan M., Bergmeier, Wolfgang
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Platelets and Thrombopoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213319/
https://ncbi.nlm.nih.gov/pubmed/30131434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-03-838714
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