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High-throughput characterization of genetic effects on DNA–protein binding and gene transcription

Many variants associated with complex traits are in noncoding regions and contribute to phenotypes by disrupting regulatory sequences. To characterize these variants, we developed a streamlined protocol for a high-throughput reporter assay, Biallelic Targeted STARR-seq (BiT-STARR-seq), that identifi...

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Detaylı Bibliyografya
Yayımlandı:Genome Res
Asıl Yazarlar: Kalita, Cynthia A., Brown, Christopher D., Freiman, Andrew, Isherwood, Jenna, Wen, Xiaoquan, Pique-Regi, Roger, Luca, Francesca
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211638/
https://ncbi.nlm.nih.gov/pubmed/30254052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.237354.118
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