High-throughput characterization of genetic effects on DNA–protein binding and gene transcription

Many variants associated with complex traits are in noncoding regions and contribute to phenotypes by disrupting regulatory sequences. To characterize these variants, we developed a streamlined protocol for a high-throughput reporter assay, Biallelic Targeted STARR-seq (BiT-STARR-seq), that identifi...

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Podrobná bibliografie
Vydáno v:Genome Res
Hlavní autoři: Kalita, Cynthia A., Brown, Christopher D., Freiman, Andrew, Isherwood, Jenna, Wen, Xiaoquan, Pique-Regi, Roger, Luca, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2018
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211638/
https://ncbi.nlm.nih.gov/pubmed/30254052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.237354.118
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