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Targeting the MAPK Pathway in RAS Mutant Cancers
Despite decades of extensive drug discovery efforts, there are currently no targeted therapies approved to treat KRAS mutant cancers. In this review, we highlight the challenges and opportunities in targeting KRAS mutant tumors through inhibition of mitogen-activated protein kinase (MAPK) signaling...
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| Publicado no: | Cold Spring Harb Perspect Med |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6211377/ https://ncbi.nlm.nih.gov/pubmed/29440321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031492 |
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