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The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants

Ras controls a multitude of cellular signaling processes, including cell proliferation, differentiation, and apoptosis. Deregulation of Ras cycling often promotes tumorigenesis and various other developmental disorders, termed RASopothies. Although the structure of Ras has been known for many decade...

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Bibliografische gegevens
Gepubliceerd in:Cold Spring Harb Perspect Med
Hoofdauteurs: Parker, Jillian A., Mattos, Carla
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071550/
https://ncbi.nlm.nih.gov/pubmed/29038336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031427
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