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The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants

Ras controls a multitude of cellular signaling processes, including cell proliferation, differentiation, and apoptosis. Deregulation of Ras cycling often promotes tumorigenesis and various other developmental disorders, termed RASopothies. Although the structure of Ras has been known for many decade...

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Bibliographic Details
Published in:Cold Spring Harb Perspect Med
Main Authors: Parker, Jillian A., Mattos, Carla
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071550/
https://ncbi.nlm.nih.gov/pubmed/29038336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031427
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