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The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants

Ras controls a multitude of cellular signaling processes, including cell proliferation, differentiation, and apoptosis. Deregulation of Ras cycling often promotes tumorigenesis and various other developmental disorders, termed RASopothies. Although the structure of Ras has been known for many decade...

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Bibliografski detalji
Izdano u:Cold Spring Harb Perspect Med
Glavni autori: Parker, Jillian A., Mattos, Carla
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071550/
https://ncbi.nlm.nih.gov/pubmed/29038336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031427
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