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Targeting RAS-mutant cancers: is ERK the key?

The three RAS genes comprise the most frequently mutated oncogene family in cancer. With significant and compelling evidence that continued function of mutant RAS is required for tumor maintenance, it is widely accepted that effective anti-RAS therapy will have a significant impact on cancer growth...

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Detalhes bibliográficos
Publicado no:Trends Cancer
Main Authors: Ryan, Meagan B., Der, Channing J., Wang-Gillam, Andrea, Cox, Adrienne D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743050/
https://ncbi.nlm.nih.gov/pubmed/26858988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trecan.2015.10.001
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