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RAS, wanted dead or alive: Advances in targeting RAS-mutant cancers

Oncogenic RAS proteins, which are mutated in approximately 24% of all human cancers, have earned a well-deserved reputation as being “undruggable.” However, several studies have challenged that reputation. With the first small molecules that directly target one oncogenic RAS mutant (G12C) undergoing...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Stalnecker, Clint A, Der, Channing J
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393681/
https://ncbi.nlm.nih.gov/pubmed/32209699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay6013
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