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Structure-Activity Relationships of Bisphosphate Nucleotide Derivatives as P2Y(1) Receptor Antagonists and Partial Agonists

The P2Y(1) receptor is present in the heart, in skeletal and various smooth muscles, and in platelets, where its activation is linked to aggregation. Adenosine 3′,5′- and 2′,5′-bisphosphates have been identified as selective antagonists at the P2Y(1) receptor (Boyer et al. Mol. Pharmacol. 1996, 50,...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Nandanan, Erathodiyil, Camaioni, Emidio, Jang, Soo-Yeon, Kim, Yong-Chul, Cristalli, Gloria, Herdewijn, Piet, Secrist, John A., Tiwari, Kamal N., Mohanram, Arvind, Harden, T. Kendall, Boyer, José L., Jacobson, Kenneth A.
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211166/
https://ncbi.nlm.nih.gov/pubmed/10229631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm980657j
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