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Human P2Y(1) Receptor: Molecular Modeling and Site-Directed Mutagenesis as Tools To Identify Agonist and Antagonist Recognition Sites

The molecular basis for recognition by human P2Y(1) receptors of the novel, competitive antagonist 2′-deoxy-N(6)-methyladenosine 3′,5′-bisphosphate (MRS 2179) was probed using site-directed mutagenesis and molecular modeling. The potency of this antagonist was measured in mutant receptors in which k...

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Main Authors: Moro, Stefano, Guo, Danping, Camaioni, Emidio, Boyer, José L., Harden, T. Kendall, Jacobson, Kenneth A.
Format: Artigo
Jezik:Inglês
Izdano: 1998
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469197/
https://ncbi.nlm.nih.gov/pubmed/9554879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm970684u
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