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Human P2Y(1) Receptor: Molecular Modeling and Site-Directed Mutagenesis as Tools To Identify Agonist and Antagonist Recognition Sites
The molecular basis for recognition by human P2Y(1) receptors of the novel, competitive antagonist 2′-deoxy-N(6)-methyladenosine 3′,5′-bisphosphate (MRS 2179) was probed using site-directed mutagenesis and molecular modeling. The potency of this antagonist was measured in mutant receptors in which k...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1998
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469197/ https://ncbi.nlm.nih.gov/pubmed/9554879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm970684u |
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