A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire

The guanine nucleotide exchange factor Vav1 is essential for transducing T cell receptor (TCR) signals and plays an important role in T cell development and activation. Previous genetic studies identified a natural variant of Vav1 characterized by the substitution of an arginine (R) residue by a try...

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Publicat a:Front Immunol
Autors principals: Bernard, Isabelle, Sacquin, Antoine, Kassem, Sahar, Benamar, Mehdi, Colacios, Céline, Gador, Mylène, Pérals, Corine, Fazilleau, Nicolas, Saoudi, Abdelhadi
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210741/
https://ncbi.nlm.nih.gov/pubmed/30410484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02399
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