Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive spread of Tau pathology throughout the brain, and several...

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Vydáno v:Acta Neuropathol
Hlavní autoři: Courade, Jean-Philippe, Angers, Rachel, Mairet-Coello, Georges, Pacico, Nathalie, Tyson, Kerry, Lightwood, Daniel, Munro, Rebecca, McMillan, David, Griffin, Robert, Baker, Terry, Starkie, Dale, Nan, Ruodan, Westwood, Marta, Mushikiwabo, Marie-Laetitia, Jung, Sophie, Odede, Geofrey, Sweeney, Berni, Popplewell, Andrew, Burgess, Gillian, Downey, Patrick, Citron, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2018
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208734/
https://ncbi.nlm.nih.gov/pubmed/30238240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1911-2
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