Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive spread of Tau pathology throughout the brain, and several...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Acta Neuropathol
Päätekijät: Courade, Jean-Philippe, Angers, Rachel, Mairet-Coello, Georges, Pacico, Nathalie, Tyson, Kerry, Lightwood, Daniel, Munro, Rebecca, McMillan, David, Griffin, Robert, Baker, Terry, Starkie, Dale, Nan, Ruodan, Westwood, Marta, Mushikiwabo, Marie-Laetitia, Jung, Sophie, Odede, Geofrey, Sweeney, Berni, Popplewell, Andrew, Burgess, Gillian, Downey, Patrick, Citron, Martin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer Berlin Heidelberg 2018
Aiheet:
Original Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208734/
https://ncbi.nlm.nih.gov/pubmed/30238240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1911-2
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