Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive spread of Tau pathology throughout the brain, and several...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol
Main Authors: Courade, Jean-Philippe, Angers, Rachel, Mairet-Coello, Georges, Pacico, Nathalie, Tyson, Kerry, Lightwood, Daniel, Munro, Rebecca, McMillan, David, Griffin, Robert, Baker, Terry, Starkie, Dale, Nan, Ruodan, Westwood, Marta, Mushikiwabo, Marie-Laetitia, Jung, Sophie, Odede, Geofrey, Sweeney, Berni, Popplewell, Andrew, Burgess, Gillian, Downey, Patrick, Citron, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2018
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208734/
https://ncbi.nlm.nih.gov/pubmed/30238240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1911-2
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