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The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

Amyloid-β 1–42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and hippocampal neurons and might play a role in early stages of Alzheimer's disease (AD) progression. Recent results suggested that Aβ42 oligomers trigger activation of AMP-activated kinase (AMPK), and its activation is i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mairet-Coello, Georges, Courchet, Julien, Pieraut, Simon, Courchet, Virginie, Maximov, Anton, Polleux, Franck
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784324/
https://ncbi.nlm.nih.gov/pubmed/23583109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.02.003
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