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Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

Of all of the neuropathological changes observed in Alzheimer’s disease (AD), the loss of synapses correlates most strongly with cognitive decline. The precise mechanisms of synapse degeneration in AD remain unclear, although strong evidence indicates that pathological forms of both amyloid beta and...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Pickett, Eleanor K., Rose, Jamie, McCrory, Caoimhe, McKenzie, Chris-Anne, King, Declan, Smith, Colin, Gillingwater, Thomas H., Henstridge, Christopher M., Spires-Jones, Tara L.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208730/
https://ncbi.nlm.nih.gov/pubmed/30191401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1903-2
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