Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, apolipoprotein E epsilon 4 (APOE4), is associated with exacerba...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Hesse, Raphael, Hurtado, Maica Llavero, Jackson, Rosemary J., Eaton, Samantha L., Herrmann, Abigail G., Colom-Cadena, Marti, Tzioras, Makis, King, Declan, Rose, Jamie, Tulloch, Jane, McKenzie, Chris-Anne, Smith, Colin, Henstridge, Christopher M., Lamont, Douglas, Wishart, Thomas M., Spires-Jones, Tara L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925519/
https://ncbi.nlm.nih.gov/pubmed/31862015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0847-7
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