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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

Synaptic dysfunction and the loss of synapses are early pathological features of Alzheimer's disease (AD). Synapses are sites of high energy demand and extensive calcium fluctuations; accordingly, synaptic transmission requires high levels of ATP and constant calcium fluctuation. Thus, synaptic...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Du, Heng, Guo, Lan, Yan, Shiqiang, Sosunov, Alexander A., McKhann, Guy M., ShiDu Yan, Shirley
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972922/
https://ncbi.nlm.nih.gov/pubmed/20937894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006586107
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