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Dissecting MMP P(10)′ and P(11)′ subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that remodel the extracellular matrix environment and mitigate outside-in signaling. Loss of regulation of MMP activity plays a role in numerous pathological states. In particular, aberrant collagenolysis affects tumor in...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6204916/ https://ncbi.nlm.nih.gov/pubmed/30185620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003266 |
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