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Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe
We report a novel activatable NIR fluorescent probe for in vivo detection of cancer-related matrix metalloproteinase (MMP) activity. The probe is based on a triple-helical peptide substrate (THP) with high specificity for MMP-2 and MMP-9 relative to other members of the MMP family. MMP-2 and MMP-9 (...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3310325/ https://ncbi.nlm.nih.gov/pubmed/22309692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc300027y |
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