Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe

We report a novel activatable NIR fluorescent probe for in vivo detection of cancer-related matrix metalloproteinase (MMP) activity. The probe is based on a triple-helical peptide substrate (THP) with high specificity for MMP-2 and MMP-9 relative to other members of the MMP family. MMP-2 and MMP-9 (...

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Bibliographic Details
Main Authors: Akers, Walter J., Xu, Baogang, Lee, Hyeran, Sudlow, Gail P., Fields, Gregg B., Achilefu, Samuel, Edwards, W. Barry
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310325/
https://ncbi.nlm.nih.gov/pubmed/22309692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc300027y
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