The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that can stimulate a variety of cells, but its overexpression leads to excessive production and activation of granulocytes and macrophages with many pathogenic effects. This cytokine is a therapeutic target in...

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Bibliografski detalji
Izdano u:MAbs
Glavni autori: Dhagat, Urmi, Hercus, Timothy R., Broughton, Sophie E., Nero, Tracy L., Cheung Tung Shing, Karen S., Barry, Emma F., Thomson, Christy A., Bryson, Steve, Pai, Emil F., McClure, Barbara J., Schrader, John W., Lopez, Angel F., Parker, Michael W.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204844/
https://ncbi.nlm.nih.gov/pubmed/29969365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1494107
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