The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that can stimulate a variety of cells, but its overexpression leads to excessive production and activation of granulocytes and macrophages with many pathogenic effects. This cytokine is a therapeutic target in...

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Veröffentlicht in:MAbs
Hauptverfasser: Dhagat, Urmi, Hercus, Timothy R., Broughton, Sophie E., Nero, Tracy L., Cheung Tung Shing, Karen S., Barry, Emma F., Thomson, Christy A., Bryson, Steve, Pai, Emil F., McClure, Barbara J., Schrader, John W., Lopez, Angel F., Parker, Michael W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204844/
https://ncbi.nlm.nih.gov/pubmed/29969365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1494107
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