The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that can stimulate a variety of cells, but its overexpression leads to excessive production and activation of granulocytes and macrophages with many pathogenic effects. This cytokine is a therapeutic target in...

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Publicado no:MAbs
Main Authors: Dhagat, Urmi, Hercus, Timothy R., Broughton, Sophie E., Nero, Tracy L., Cheung Tung Shing, Karen S., Barry, Emma F., Thomson, Christy A., Bryson, Steve, Pai, Emil F., McClure, Barbara J., Schrader, John W., Lopez, Angel F., Parker, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204844/
https://ncbi.nlm.nih.gov/pubmed/29969365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1494107
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