The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that can stimulate a variety of cells, but its overexpression leads to excessive production and activation of granulocytes and macrophages with many pathogenic effects. This cytokine is a therapeutic target in...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Dhagat, Urmi, Hercus, Timothy R., Broughton, Sophie E., Nero, Tracy L., Cheung Tung Shing, Karen S., Barry, Emma F., Thomson, Christy A., Bryson, Steve, Pai, Emil F., McClure, Barbara J., Schrader, John W., Lopez, Angel F., Parker, Michael W.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204844/
https://ncbi.nlm.nih.gov/pubmed/29969365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1494107
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