Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis

Comparative analyses of the four known anthraquinone-fused enediynes biosynthetic gene clusters identified four genes, tnmE6, tnmH, tnmL, and tnmQ, unique to the tnm gene cluster. Larger scale fermentation of both the S. sp. CB03234 wild-type and the ΔtnmH and ΔtnmL mutant strains resulted in the ch...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Org Lett
Autori principali: Yan, Xiaohui, Chen, Jian-Jun, Adhikari, Ajeeth, Teijaro, Christiana N., Ge, Huiming, Crnovcic, Ivana, Chang, Chin-Yuan, Annaval, Thibault, Yang, Dong, Rader, Christoph, Shen, Ben
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204227/
https://ncbi.nlm.nih.gov/pubmed/30212211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b02584
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi