A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in vivo near genome-wide, functional screen in Drosoph...

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Publicado en:PLoS Genet
Autores principales: Zoranovic, Tamara, Manent, Jan, Willoughby, Lee, Matos de Simoes, Ricardo, La Marca, John E., Golenkina, Sofya, Cuiping, Xia, Gruber, Susanne, Angjeli, Belinda, Kanitz, Elisabeth Eva, Cronin, Shane J. F., Neely, G. Gregory, Wernitznig, Andreas, Humbert, Patrick O., Simpson, Kaylene J., Mitsiades, Constantine S., Richardson, Helena E., Penninger, Josef M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203380/
https://ncbi.nlm.nih.gov/pubmed/30325918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007688
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