A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in vivo near genome-wide, functional screen in Drosoph...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS Genet
मुख्य लेखकों: Zoranovic, Tamara, Manent, Jan, Willoughby, Lee, Matos de Simoes, Ricardo, La Marca, John E., Golenkina, Sofya, Cuiping, Xia, Gruber, Susanne, Angjeli, Belinda, Kanitz, Elisabeth Eva, Cronin, Shane J. F., Neely, G. Gregory, Wernitznig, Andreas, Humbert, Patrick O., Simpson, Kaylene J., Mitsiades, Constantine S., Richardson, Helena E., Penninger, Josef M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2018
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203380/
https://ncbi.nlm.nih.gov/pubmed/30325918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007688
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