A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in vivo near genome-wide, functional screen in Drosoph...

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Vydáno v:PLoS Genet
Hlavní autoři: Zoranovic, Tamara, Manent, Jan, Willoughby, Lee, Matos de Simoes, Ricardo, La Marca, John E., Golenkina, Sofya, Cuiping, Xia, Gruber, Susanne, Angjeli, Belinda, Kanitz, Elisabeth Eva, Cronin, Shane J. F., Neely, G. Gregory, Wernitznig, Andreas, Humbert, Patrick O., Simpson, Kaylene J., Mitsiades, Constantine S., Richardson, Helena E., Penninger, Josef M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203380/
https://ncbi.nlm.nih.gov/pubmed/30325918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007688
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