A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways. We devised an in vivo near genome-wide, functional screen in Drosoph...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Zoranovic, Tamara, Manent, Jan, Willoughby, Lee, Matos de Simoes, Ricardo, La Marca, John E., Golenkina, Sofya, Cuiping, Xia, Gruber, Susanne, Angjeli, Belinda, Kanitz, Elisabeth Eva, Cronin, Shane J. F., Neely, G. Gregory, Wernitznig, Andreas, Humbert, Patrick O., Simpson, Kaylene J., Mitsiades, Constantine S., Richardson, Helena E., Penninger, Josef M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203380/
https://ncbi.nlm.nih.gov/pubmed/30325918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007688
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