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ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance
Certain commensal Escherichia coli contain the clb biosynthetic gene cluster that codes for small molecule prodrugs known as precolibactins. Precolibactins are converted to colibactins by N-deacylation; the latter are postulated to be genotoxic and to contribute to colorectal cancer formation. Thoug...
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| 出版年: | J Am Chem Soc |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202678/ https://ncbi.nlm.nih.gov/pubmed/29112397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09971 |
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