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Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway

Colibactin is a genotoxic hybrid nonribosomal peptide/polyketide secondary metabolite produced by various pathogenic and probiotic bacteria residing in the human gut. The presence of colibactin metabolites has been correlated to colorectal cancer formation in several studies. The specific function o...

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Publicat a:ACS Chem Biol
Autors principals: Guntaka, Naga Sandhya, Healy, Alan R., Crawford, Jason M., Herzon, Seth B., Bruner, Steven D.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830302/
https://ncbi.nlm.nih.gov/pubmed/28846367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00479
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