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Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway

Colibactin is a genotoxic hybrid nonribosomal peptide/polyketide secondary metabolite produced by various pathogenic and probiotic bacteria residing in the human gut. The presence of colibactin metabolites has been correlated to colorectal cancer formation in several studies. The specific function o...

詳細記述

保存先:
書誌詳細
出版年:ACS Chem Biol
主要な著者: Guntaka, Naga Sandhya, Healy, Alan R., Crawford, Jason M., Herzon, Seth B., Bruner, Steven D.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830302/
https://ncbi.nlm.nih.gov/pubmed/28846367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00479
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