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Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway

Colibactin is a genotoxic hybrid nonribosomal peptide/polyketide secondary metabolite produced by various pathogenic and probiotic bacteria residing in the human gut. The presence of colibactin metabolites has been correlated to colorectal cancer formation in several studies. The specific function o...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Guntaka, Naga Sandhya, Healy, Alan R., Crawford, Jason M., Herzon, Seth B., Bruner, Steven D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830302/
https://ncbi.nlm.nih.gov/pubmed/28846367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00479
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