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Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway

Colibactin is a genotoxic hybrid nonribosomal peptide/polyketide secondary metabolite produced by various pathogenic and probiotic bacteria residing in the human gut. The presence of colibactin metabolites has been correlated to colorectal cancer formation in several studies. The specific function o...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Chem Biol
Main Authors: Guntaka, Naga Sandhya, Healy, Alan R., Crawford, Jason M., Herzon, Seth B., Bruner, Steven D.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830302/
https://ncbi.nlm.nih.gov/pubmed/28846367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00479
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