Mitochondrial‐Mediated Oxidative Ca(2+)/Calmodulin‐Dependent Kinase II Activation Induces Early Afterdepolarizations in Guinea Pig Cardiomyocytes: An In Silico Study

BACKGROUND: Oxidative stress–mediated Ca(2+)/calmodulin‐dependent protein kinase II (CaMKII) phosphorylation of cardiac ion channels has emerged as a critical contributor to arrhythmogenesis in cardiac pathology. However, the link between mitochondrial‐derived reactive oxygen species (mdROS) and inc...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Yang, Ruilin, Ernst, Patrick, Song, Jiajia, Liu, Xiaoguang M., Huke, Sabine, Wang, Shuxin, Zhang, Jianyi Jay, Zhou, Lufang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201444/
https://ncbi.nlm.nih.gov/pubmed/30371234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.008939
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