Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats

Intervertebral disc degeneration (IVDD) is one of the major causes of low back pain. Polydatin (PD) has been shown to exert multiple pharmacological effects on different diseases; here, we test the therapeutic potential of PD for IVDD. In in‐vitro experiments, we confirmed PD is nontoxic to nucleus...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Wang, Jianle, Huang, Chongan, Lin, Zongze, Pan, Xiangxiang, Chen, Jiaoxiang, Zheng, Gang, Tian, Naifeng, Yan, Yingzhao, Zhang, Zengjie, Hu, Jianing, Cheng, Pu, Wang, Xiangyang, Zhang, Xiaolei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201341/
https://ncbi.nlm.nih.gov/pubmed/30358118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13848
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