Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats

Intervertebral disc degeneration (IVDD) is one of the major causes of low back pain. Polydatin (PD) has been shown to exert multiple pharmacological effects on different diseases; here, we test the therapeutic potential of PD for IVDD. In in‐vitro experiments, we confirmed PD is nontoxic to nucleus...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Wang, Jianle, Huang, Chongan, Lin, Zongze, Pan, Xiangxiang, Chen, Jiaoxiang, Zheng, Gang, Tian, Naifeng, Yan, Yingzhao, Zhang, Zengjie, Hu, Jianing, Cheng, Pu, Wang, Xiangyang, Zhang, Xiaolei
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201341/
https://ncbi.nlm.nih.gov/pubmed/30358118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13848
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