Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

Intervertebral disc degeneration (IDD) is a complicated process that involves both cellular apoptosis and senescence. Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence. Therefore, we hypothesize that metformin may have therapeu...

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Vydáno v:Cell Death Dis
Hlavní autoři: Chen, Deheng, Xia, Dongdong, Pan, Zongyou, Xu, Daoliang, Zhou, Yifei, Wu, Yaosen, Cai, Ningyu, Tang, Qian, Wang, Chenggui, Yan, Meijun, Zhang, Jing Jie, Zhou, Kailiang, Wang, Quan, Feng, Yongzeng, Wang, Xiangyang, Xu, Huazi, Zhang, Xiaolei, Tian, Naifeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133996/
https://ncbi.nlm.nih.gov/pubmed/27787519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.334
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