Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

Intervertebral disc degeneration (IDD) is a complicated process that involves both cellular apoptosis and senescence. Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence. Therefore, we hypothesize that metformin may have therapeu...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chen, Deheng, Xia, Dongdong, Pan, Zongyou, Xu, Daoliang, Zhou, Yifei, Wu, Yaosen, Cai, Ningyu, Tang, Qian, Wang, Chenggui, Yan, Meijun, Zhang, Jing Jie, Zhou, Kailiang, Wang, Quan, Feng, Yongzeng, Wang, Xiangyang, Xu, Huazi, Zhang, Xiaolei, Tian, Naifeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133996/
https://ncbi.nlm.nih.gov/pubmed/27787519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.334
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