Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

Intervertebral disc degeneration (IDD) is a complicated process that involves both cellular apoptosis and senescence. Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence. Therefore, we hypothesize that metformin may have therapeu...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Death Dis
Autors principals: Chen, Deheng, Xia, Dongdong, Pan, Zongyou, Xu, Daoliang, Zhou, Yifei, Wu, Yaosen, Cai, Ningyu, Tang, Qian, Wang, Chenggui, Yan, Meijun, Zhang, Jing Jie, Zhou, Kailiang, Wang, Quan, Feng, Yongzeng, Wang, Xiangyang, Xu, Huazi, Zhang, Xiaolei, Tian, Naifeng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133996/
https://ncbi.nlm.nih.gov/pubmed/27787519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.334
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars