Promoting Nrf2/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration

One of the causes of intervertebral disc degeneration (IVDD) is nucleus pulposus cell (NPC) death, possibly apoptosis. In this study, we explored the role of the Nrf2/Sirt3 pathway and tert-butylhydroquinone (t-BHQ) in IVDD and elucidated the potential working mechanism. Reactive oxygen species (ROS...

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Bibliografski detalji
Izdano u:Oxid Med Cell Longev
Glavni autori: Hu, Sunli, Zhang, Chenxi, Qian, Tianchen, Bai, Yue, Chen, Liang, Chen, Jiaoxiang, Huang, Chongan, Xie, Chenglong, Wang, Xiangyang, Jin, Haiming
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2021
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Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211502/
https://ncbi.nlm.nih.gov/pubmed/34211633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6694964
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