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Promoting Nrf2/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration

One of the causes of intervertebral disc degeneration (IVDD) is nucleus pulposus cell (NPC) death, possibly apoptosis. In this study, we explored the role of the Nrf2/Sirt3 pathway and tert-butylhydroquinone (t-BHQ) in IVDD and elucidated the potential working mechanism. Reactive oxygen species (ROS...

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Bibliographische Detailangaben
Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Hu, Sunli, Zhang, Chenxi, Qian, Tianchen, Bai, Yue, Chen, Liang, Chen, Jiaoxiang, Huang, Chongan, Xie, Chenglong, Wang, Xiangyang, Jin, Haiming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211502/
https://ncbi.nlm.nih.gov/pubmed/34211633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6694964
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