Promoting Nrf2/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration

One of the causes of intervertebral disc degeneration (IVDD) is nucleus pulposus cell (NPC) death, possibly apoptosis. In this study, we explored the role of the Nrf2/Sirt3 pathway and tert-butylhydroquinone (t-BHQ) in IVDD and elucidated the potential working mechanism. Reactive oxygen species (ROS...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oxid Med Cell Longev
Päätekijät: Hu, Sunli, Zhang, Chenxi, Qian, Tianchen, Bai, Yue, Chen, Liang, Chen, Jiaoxiang, Huang, Chongan, Xie, Chenglong, Wang, Xiangyang, Jin, Haiming
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Hindawi 2021
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211502/
https://ncbi.nlm.nih.gov/pubmed/34211633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6694964
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