Promoting Nrf2/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration

One of the causes of intervertebral disc degeneration (IVDD) is nucleus pulposus cell (NPC) death, possibly apoptosis. In this study, we explored the role of the Nrf2/Sirt3 pathway and tert-butylhydroquinone (t-BHQ) in IVDD and elucidated the potential working mechanism. Reactive oxygen species (ROS...

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Dettagli Bibliografici
Pubblicato in:Oxid Med Cell Longev
Autori principali: Hu, Sunli, Zhang, Chenxi, Qian, Tianchen, Bai, Yue, Chen, Liang, Chen, Jiaoxiang, Huang, Chongan, Xie, Chenglong, Wang, Xiangyang, Jin, Haiming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211502/
https://ncbi.nlm.nih.gov/pubmed/34211633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6694964
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