Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration

Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of intervertebral disc degeneration (IVDD). Sirtuin 3 (SIRT3), a sirtuin family protein located in mitochondria, is essential for mitochondrial homeostasis; however, the role of SIRT3 in the process of IVDD has rema...

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Veröffentlicht in:Exp Mol Med
Hauptverfasser: Wang, Jianle, Nisar, Majid, Huang, Chongan, Pan, Xiangxiang, Lin, Dongdong, Zheng, Gang, Jin, Haiming, Chen, Deheng, Tian, Naifeng, Huang, Qianyu, Duan, Yue, Yan, Yingzhao, Wang, Ke, Wu, Congcong, Hu, Jianing, Zhang, Xiaolei, Wang, Xiangyang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232087/
https://ncbi.nlm.nih.gov/pubmed/30420619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-018-0173-3
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