Frontal Affinity Chromatography—Mass Spectrometry Useful for Characterization of New Ligands for GPR17 Receptor

The application of frontal affinity chromatography−mass spectrometry (FAC−MS), along with molecular modeling studies, to the screening of potential drug candidates toward the recently deorphanized G-protein-coupled receptor (GPCR) GPR17 is shown. GPR17 is dually activated by uracil nucleotides and c...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Calieri, Enrica, Ceruti, Stefania, Cristalli, Gloria, Martini, Claudia, Temporini, Caterina, Parravicini, Chiara, Volpini, Rosaria, Daniele, Simona, Caccialanza, Gabriele, Lecca, Davide, Lambertucci, Catia, Trincavelli, Maria Letizia, Marucci, Gabriella, Wainer, Irving W., Ranghino, Graziella, Fantucci, Piercarlo, Abbraccino, Maria P., Massolini, Gabriella
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201305/
https://ncbi.nlm.nih.gov/pubmed/20394377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901691y
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