Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17

In this work, an innovative and non-radioactive functional cAMP assay was validated at the GPR17 receptor. This assay provides a simple and powerful new system to monitor G protein-coupled receptor activity through change in the intracellular cAMP concentration by using a mutant form of Photinus pyr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Buccioni, Michela, Marucci, Gabriella, Dal Ben, Diego, Giacobbe, Dania, Lambertucci, Catia, Soverchia, Laura, Thomas, Ajiroghene, Volpini, Rosaria, Cristalli, Gloria
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Netherlands 2011
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224640/
https://ncbi.nlm.nih.gov/pubmed/21773766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-011-9245-8
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