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Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are modest for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due to th...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Antimicrob Agents Chemother
Κύριοι συγγραφείς: Keniya, Mikhail V., Ruma, Yasmeen N., Tyndall, Joel D. A., Monk, Brian C.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2018
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201088/
https://ncbi.nlm.nih.gov/pubmed/30126959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01131-18
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