In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy

VT-1129 is a novel fungal enzyme-specific Cyp51 inhibitor with potent cryptococcal activity. Because of its long half-life (>6 days in mice) and our desire to quickly reach potent efficacy, we evaluated a VT-1129 loading dose-maintenance dose strategy against cryptococcal meningitis. VT-1129 plas...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Wiederhold, Nathan P., Xu, Xin, Wang, Amy, Najvar, Laura K., Garvey, Edward P., Ottinger, Elizabeth A., Alimardanov, Asaf, Cradock, Jim, Behnke, Mark, Hoekstra, William J., Brand, Stephen R., Schotzinger, Robert J., Jaramillo, Rosie, Olivo, Marcos, Kirkpatrick, William R., Patterson, Thomas F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2018
Ábhair:
Experimental Therapeutics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201077/
https://ncbi.nlm.nih.gov/pubmed/30104280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01315-18
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