The lineage defining transcription factors SOX2 and NKX2-1 determine lung cancer cell fate and shape the tumor immune microenvironment

The major types of non-small cell lung cancer (NSCLC) - squamous cell carcinoma and adenocarcinoma - have distinct immune microenvironments. We developed a genetic model of squamous NSCLC based on overexpression of the transcription factor Sox2, which specifies lung basal cell fate, and loss of the...

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Publicat a:Immunity
Autors principals: Mollaoglu, Gurkan, Jones, Alex, Wait, Sarah J., Mukhopadhyay, Anandaroop, Jeong, Sangmin, Arya, Rahul, Camolotto, Soledad A., Mosbruger, Timothy L., Stubben, Chris J., Conley, Christopher J., Bhutkar, Arjun, Vahrenkamp, Jeffery M., Berrett, Kristofer C., Cessna, Melissa H., Lane, Thomas, Witt, Benjamin L., Salama, Mohamed E., Gertz, Jason, Jones, Kevin B., Snyder, Eric L., Oliver, Trudy G.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197489/
https://ncbi.nlm.nih.gov/pubmed/30332632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.09.020
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