MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to Aurora kinase inhibition

Loss of the tumor suppressors RB1 and TP53 and MYC amplification are frequent oncogenic events in small cell lung cancer (SCLC). We show that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemother...

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Publicado no:Cancer Cell
Main Authors: Mollaoglu, Gurkan, Guthrie, Matthew R., Böhm, Stefanie, Brägelmann, Johannes, Can, Ismail, Ballieu, Paul M., Marx, Annika, George, Julie, Heinen, Christine, Chalishazar, Milind D., Cheng, Haixia, Ireland, Abbie S., Denning, Kendall E., Mukhopadhyay, Anandaroop, Vahrenkamp, Jeffery M., Berrett, Kristofer C., Mosbruger, Timothy L., Wang, Jun, Kohan, Jessica L., Salama, Mohamed E., Witt, Benjamin L., Peifer, Martin, Thomas, Roman K., Gertz, Jason, Johnson, Jane E., Gazdar, Adi F., Wechsler-Reya, Robert J., Sos, Martin L., Oliver, Trudy G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5310991/
https://ncbi.nlm.nih.gov/pubmed/28089889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.12.005
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