Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancer

Estrogen receptor 1 (ESR1) mutations have been identified in hormone therapy–resistant breast cancer and primary endometrial cancer. Analyses in breast cancer suggest that mutant ESR1 exhibits estrogen-independent activity. In endometrial cancer, ESR1 mutations are associated with worse outcomes and...

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Bibliographic Details
Published in:Genome Res
Main Authors: Blanchard, Zannel, Vahrenkamp, Jeffery M., Berrett, Kristofer C., Arnesen, Spencer, Gertz, Jason
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724674/
https://ncbi.nlm.nih.gov/pubmed/31362937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.244780.118
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