The lineage defining transcription factors SOX2 and NKX2-1 determine lung cancer cell fate and shape the tumor immune microenvironment

The major types of non-small cell lung cancer (NSCLC) - squamous cell carcinoma and adenocarcinoma - have distinct immune microenvironments. We developed a genetic model of squamous NSCLC based on overexpression of the transcription factor Sox2, which specifies lung basal cell fate, and loss of the...

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Publicado no:Immunity
Main Authors: Mollaoglu, Gurkan, Jones, Alex, Wait, Sarah J., Mukhopadhyay, Anandaroop, Jeong, Sangmin, Arya, Rahul, Camolotto, Soledad A., Mosbruger, Timothy L., Stubben, Chris J., Conley, Christopher J., Bhutkar, Arjun, Vahrenkamp, Jeffery M., Berrett, Kristofer C., Cessna, Melissa H., Lane, Thomas, Witt, Benjamin L., Salama, Mohamed E., Gertz, Jason, Jones, Kevin B., Snyder, Eric L., Oliver, Trudy G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197489/
https://ncbi.nlm.nih.gov/pubmed/30332632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.09.020
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