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Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide‐rich de novo designed peptides

Disulfide‐rich peptides represent an important protein family with broad pharmacological potential. Recent advances in computational methods have made it possible to design new peptides which adopt a stable conformation de novo. Here, we describe a system to produce disulfide‐rich de novo peptides u...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Buchko, Garry W., Pulavarti, Surya V.S.R.K., Ovchinnikov, Victor, Shaw, Elizabeth A., Rettie, Stephen A., Myler, Peter J., Karplus, Martin, Szyperski, Thomas, Baker, David, Bahl, Christopher D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194292/
https://ncbi.nlm.nih.gov/pubmed/30152054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3453
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