Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic

The heart exhibits the highest basal oxygen (O(2)) consumption per tissue mass of any organ in the body and is uniquely dependent on aerobic metabolism to sustain contractile function. During acute hypoxic states, the body responds with a compensatory increase in cardiac output that further increase...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Boehme, Jason, Le Moan, Natacha, Kameny, Rebecca J., Loucks, Alexandra, Johengen, Michael J., Lesneski, Amy L., Gong, Wenhui, Goudy, Brian D., Davis, Tina, Tanaka, Kevin, Davis, Andrew, He, Youping, Long-Boyle, Janel, Ivaturi, Vijay, Gobburu, Jogarao V. S., Winger, Jonathan A., Cary, Stephen P., Datar, Sanjeev A., Fineman, Jeffrey R., Krtolica, Ana, Maltepe, Emin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193608/
https://ncbi.nlm.nih.gov/pubmed/30335746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005924
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