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TMIC-15. OMX IS A TUMOR MICROENVIRONMENT MODIFIER THAT RESTORES ANTI-TUMOR IMMUNITY AND IMPROVES ANTI-TUMOR EFFICACY BY REDUCING TUMOR HYPOXIA IN INTRACRANIAL GLIOBLASTOMA MOUSE MODEL

BACKGROUND: Intratumoral hypoxia is associated with resistance to chemo- and radio-therapies and poor patient outcomes. In addition, hypoxia promotes the immune escape of tumors by altering the recruitment and function of innate and adaptive immune effector and suppressor cells. Therefore, reversing...

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Publicat a:Neuro Oncol
Autors principals: Le Moan, Natacha, Davis, Tina, Leung, Philberta, Ng, Sarah, Winger, Jonathan, Cary, Stephen, Butowski, Nicholas, Krtolica, Ana
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216340/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1074
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