ET-31 RADIOSENSITIZATION BY OMX-4.80P, A PEGylated H-NOX OXYGEN CARRIER THAT PENETRATES AND OXYGENATES HYPOXIC TUMORS, IN PRECLINICAL MODELS OF GLIOBLASTOMA AND OTHER HYPOXIC CANCERS

BACKGROUND: Omniox has engineered OMX-4.80P, a PEGylated H-NOX oxygen carrier, as a long-acting therapeutic candidate to enhance radiotherapy (RT) in the treatment of glioblastoma (GB) and other solid tumors. We have previously described the un-PEGylated OMX-4.80 variant, which can penetrate intracr...

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Main Authors: Krtolica, Ana, Le Moan, Natacha, Getz, Jen, Davis, Tina, Ng, Sarah, Bedard, Catherine, Davis, Andrew, Leung, Philberta, Serwer, Laura, Tanaka, Kevin, Keating, Tim, Yan, Feng, Winger, Jonathan, Cary, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218128/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.31
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