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P06.04 By reversing tumor hypoxia, omx, an ind-stage drug candidate, promotes anti-tumor response and increases survival in the gl261 intracranial glioblastoma model
Intratumoral hypoxia is a common feature in solid tumors such as glioblastoma (GB). Hypoxic tumor cells develop aggressive phenotypes and resistance to chemo- and radio-therapies leading to poor patient outcomes. In addition, hypoxia promotes the immune escape of tumors via Treg recruitment and acti...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5463933/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.178 |
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