Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling

The constitutive androstane receptor (CAR) is a nuclear receptor involved mainly in xenobiotic and endobiotic metabolism regulation. CAR is activated directly by its ligands via the ligand binding domain (LBD) or indirectly by inhibition of the epidermal growth factor (EGF) signaling. We found that...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Carazo, Alejandro, Dusek, Jan, Holas, Ondrej, Skoda, Josef, Hyrsova, Lucie, Smutny, Tomas, Soukup, Tomas, Dosedel, Martin, Pávek, Petr
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193428/
https://ncbi.nlm.nih.gov/pubmed/30364229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00993
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